The article provides  an overview of local medicines used in wounds’ treatment  for patients with purulo-necrotic complications of diabetic foot syndrome (DFS) and the requirements  for these preparations  at the present-day stage of wound healing process development and also the principles of monitoring  of  wounds of different etiology. The above material also allows you to get acquainted with the classification of local medicines groups, their brief characteristics with highlighting the peculiarity of each group, strengths and weaknesses, indications, contraindications and possible mistakes of their using. Here is given the detailed description of  main groups modern wound coverings based on alginates, hydrocolloids, hydrogels and histo-equivalent-bioplastic material of hyaluronic acid. There were made conclusions about the lack of information on the real clinical effectiveness of modern dressings and about  numerous and not systematic approaches for measuring the course of the wound healing process using various biological models. This explains the urgency to improving the modern diagnostic algorithm for measuring the course of the wound healing process and the need to develop an universal model that allows to identify its peculiarities and regularities, including efficiency assessment for local treatment of DFS purulo-necrotic complications.

Immobilization of various therapeutic agents on biodegradable carriers facilitates the active participation of therapeutic materials in the wound healing process. Selective accumulation of the drug in the lesion allows simultaneously solving several problems: increase the efficacy of the drug, reduce its consumption, and eliminate the undesirable effects of the drug on healthy organs and tissues.

The main purpose of this study: ·  the creation of high-performance wound coverings of a new generation for medical purpose, the creation and development of industrial technology for their production; · 

multidimensional studies of the obtained immobilized therapeutic agents on modified polysaccharide carriers. 

Object. The study of the informativeness by various methods of visualizing the dimensions of wound defects and the dynamics of their healing in patients with diabetic foot syndrome (DFS).

Materials and Methods. The descriptive research analyzed various methods for determining the size of wounds in 77 patients with DFS. 63 (81.8 %) patients (1st group) were performed classical planimetry by film using. The wound size at 6 (7.8 %) patients (2nd group) was estimated by using a computer program, 8 (10.4 %) patients (3d group) underwent magnetic resonance imaging (MRI) their feet.

Results. In the course of the study, the median area of wounds in Group 1 patients were 25.0 [16.2; 44.5] cm2, median depth — 3.3 [1.5; 6.5] cm. It was required about 15–20 minutes of the expert work. The median area of wounds by patients Group 2, measured with the mobile application V2F, was 8.95 [6.8; 10.6] cm2. The depth determined by the same method was 0.25 [0.2; 0.5] cm. The study duration amount to 5 minutes approximately. The 3d patients Group that was measured with MRI had wound defects depth equal to 3.2 [2.6; 4.5] cm, wound area - 23.5 [12.3; 55.3] cm2. This study duration was similar to the standard MRI protocol.

Conclusion. The planimetric method of wound size analysis is a routine way for assessing the dynamics of the wound defects state, its size and depth. Determining the size of wounds with special software is rather quick and simple method, but it allows to evaluate only the planar characteristics of the wound and has a high error. The MRI procedure of a wound with an alginate dressing allows to reliably estimate the volume of wound defect and exclude the presence of a hidden infection focus.

This article presents the successful treatment experience of a patient with purulent sacroiliitis, complicated by an extensive retroperitoneal phlegmon. Due to the comprehensive approach, that includes two-stage surgical treatment and medication therapy, the patient was fully recovered.

Diabetic neuroosteoarthropathy (DNOAP) is a serious diabetes melitus complication leading to the limb loss. There was developed several ways for surgical correction of foot deformation at DNOAP in recent years, however, there is no much known about their use long-term results. This article presents the successful complex treatment and 10-years outcomes results in patient with type 2 diabetes and both feet deformation due to the DNOAP.