HIGH-VOLUME HEMOFILTRATION REGIMENS IN THE INTENSIVE THERAPY OF SEVERE SEPSIS AND SEPTIC SHOCK
https://doi.org/10.17650/2408-9613-2015-2-2-40-45
Abstract
Background. The paper gives the results of a clinical trial using different high-volume hemofiltration regimens in surgical patients with severe sepsis and septic shock. Objective: to improve clinical outcomes in patients with severe sepsis and septic shock, by incorporating high-volume hemofiltration regimens into combination intensive therapy. Subjects and methods. The investigation enrolled 46 patients. Twenty-four patients underwent intermittent very high-volume hemofiltration (IHVH) with a replacement volume of 100 ml / kg / h for 4 hours and 22 had continuous high-volume hemofiltration (CHVH) with a dose of 50 ml / kg / h for 48 hours. Results. In the IHVH group, 28-day mortality was 29.2 %, which significantly differed from that in the CHVH group (40.9 %). The investigation revealed contraindications to IHVH in patient with a body mass index of more than 25 kg / m2.
About the Authors
A. N. Kudryavtsev
A. V. Vishnevsky Institute of Surgery, Ministry of Health of Russia
Russian Federation
Russian Federation
V. V. Kulabukhov
A. V. Vishnevsky Institute of Surgery, Ministry of Health of Russia
Russian Federation
Russian Federation
A. G. Chizhov
A. V. Vishnevsky Institute of Surgery, Ministry of Health of Russia
Russian Federation
Russian Federation
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For citations:
Kudryavtsev A.N., Kulabukhov V.V., Chizhov A.G. HIGH-VOLUME HEMOFILTRATION REGIMENS IN THE INTENSIVE THERAPY OF SEVERE SEPSIS AND SEPTIC SHOCK. Wounds and wound infections. The prof. B.M. Kostyuchenok journal. 2015;2(2):40-45. (In Russ.) https://doi.org/10.17650/2408-9613-2015-2-2-40-45
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