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Clinical observation of the effective use of the collagen biological dressing “Digestol” in a patient with diabetic foot syndrome and multiple complications of diabetes mellitus

https://doi.org/10.25199/2408-9613-2025-12-2-30-36

Abstract

The article presents a clinical case of successful treatment of a patient with diabetic foot syndrome and multiple late complications of diabetes mellitus, whose local treatment protocol collagen biological dressings (Digestol, Zelenaya Dubrava CJSC, Russia).

About the Authors

E. L. Zaitseva
I. I. Dedov National Medical Research Center ofEndocrinology
Russian Federation

Ekaterina L. Zaitseva – MD, Cand. Sci. (Med.), endocrinologist

11 Dmitrya Ulyanova Str., Moscow, 117292



G. R. Galstyan
I. I. Dedov National Medical Research Center ofEndocrinology
Russian Federation

Gagik R. Galstyan – MD, Dr. Sci. (Med.), Professor, endocrinologist

11 Dmitrya Ulyanova Str., Moscow, 117292



References

1. IDF Diabetes Atlas = Atlas diabeta IDF. 11-ye izd. 2025. (In Russ).

2. Wollina U., Schmidt W., Krönert C., et al. Some effects of a topical collagen-based matrix on the microcirculation and wound healing in patients with chronic venous leg ulcers: preliminary observations. Int J Low Extrem Wounds. 2005; 4 (4): 214–224.

3. Cullen B., Ivins N. Promogran & Promo gran Prisma Made easy. Wounds international. 2010; 1 (3): 1–6.

4. Cullen B., Watt P., Lundqvist C., et al. The role of oxidized regenerated cellulose/collagen in chronic wound repair and its potential mechanism of action. Int J Biochem Cell Biol. 2002; 34 (12): 1544–1556.

5. Cullen B., Kemp L., Essler L., et al. Re balancing wound biochemistry improves healing: a clinical study examining effect of Promogran. Wound Repair and Regeneration. 2004; 12 (2): A4–A4.

6. Lobmann R., Zemlin C., Motzkau M., et al. Expression of metalloproteinases and growth factors in diabetic wounds treated with a protease absorbent dressing. J Diabetes Complications. 2006; 20 (5): 329–335.

7. Cullen B., Watt P., Lundqvist C., et al. The role of oxidized regenerated cellulose/collagen in chronic wound repair and its potential mechanism of action. Int J Biochem Cell Biol. 2002; 34 (12): 1544–1556.

8. Veves A., Akbari C.M., Primavera J., et al. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease and foot ulceration. Diabetes. 1998; 47: 457–463.

9. Tokmakova A. Yu., Zaitseva E. L., Doroni na L. P., et al. Effect of local application of collagen on the activity of reparative processes in soft tissues of the lower extremities in patients with diabetic foot syndrome = Tokmakova A. Yu., Zayt seva Ye .L., Doronina L. P. i dr. Vliyaniye mestnogo primeneniya kollagena na aktivnost’ reparativnykh protsessov v myagkikh tkanyakh nizhnikh konechnostey u bol’nykh s sindromom diabeticheskoy stopy. Terapevticheskiy arkhiv. 2015; 87 (10): 72–79. (In Russ).

10. СStrakhova G. Yu., Arbuzova M. I., Tokmakova A. Yu. Efficiency of collagen-containing dressings in the complex therapy of chronic wound defects in patients with diabetes mellitus = Strakhova G. Yu., Arbuzova M. I., Tokmakova A. Yu. Effektivnost’ kollagensoderzhashchikh povyazok v kompleksnoy terapii khronicheskikh ranevykh defektov u bol’nykh sakharnym diabetom. Sakharnyy diabet. 2007; 10 (4): 30–34. (In Russ).

11. Mayorova A. V., Sysuev B. B., Ivankova Yu. O., Khanalieva I. A. Collagenases in medical practice: modern collagenase-based products and prospects for their improvement = Mayorova A. V., Sys uyev B. B., Ivankova Yu. O., Khanaliyeva I. A. Kollagenazy v meditsinskoy praktike: sovremennyye sredstva na osnove kollagenazy i perspektivyikh sovershenstvovaniya. Farmatsiya i farmakologiya. 2019; 7 (5): 260–270. (In Russ).

12. Kashtanov A. D., Vasiliev Yu. L., Kuzin A. N., Chilikov V. V. Experience of using the non-contact thermometry method in assessing the effectiveness of treating small shallow wounds with impaired trophism with the bio logical dressing “Digestol” = Kashtanov A. D., Vasil’yev Yu. L., Kuzin A. N., Chilikov V. V. Opyt ispol’zovaniya metoda beskontaktnoy termometrii v otsenke effektivnosti lecheniya malykh neglubokikh ran s narusheniyem trofiki povyazkoy biologicheskoy “Digestol”. Op erativnaya khirurgiya i klinicheskaya anatomiya (Pirogovskiy nauchnyy zhurnal). 2019; 3 (4): 21–27. (In Russ).

13. Maksimova N. V., Kovylov A. O. Biological dressings based on collagen in the treatment of chronic wounds in diabetic foot syndrome = Maksimova N. V., Kovylov A. O. Biologicheskiye povyazki na osnove kollagena v lechenii khronicheskikh ran pri sindrome diabeticheskoy stopy. Khirurgiya. Zhurnal im. N. I. Pirogova. 2022; 12: 109 116. (In Russ).


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For citations:


Zaitseva E.L., Galstyan G.R. Clinical observation of the effective use of the collagen biological dressing “Digestol” in a patient with diabetic foot syndrome and multiple complications of diabetes mellitus. Wounds and wound infections. The prof. B.M. Kostyuchenok journal. 2025;12(2):30-36. (In Russ.) https://doi.org/10.25199/2408-9613-2025-12-2-30-36

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ISSN 2408-9613 (Print)
ISSN 2500-0594 (Online)
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