Surgical treatment of necrotizing fasciitis in the myelodysplastic syndrome in a child
https://doi.org/10.25199/2408-9613-2022-9-2-34-43
Abstract
Myelodysplastic syndromes are clonal stem cell diseases characterized by hematopoietic dysplasia taking place in one or more myeloid cell lines, as well as by a high risk of progression to acute myeloid leukemia. This systemic disease is often accompanied by the violated microcirculation in the skin due to thrombosis of the terminal arteries leading to the formation of necrotic zones. The multicomponent nature of the disease requires a multidisciplinary approach to the treatment and staged surgical intervention. In this article, we present an example of a successful complex treatment of a 16-year-old girl with soft tissue necrosis of the perineum which developed because of the myelodysplastic syndrome.
Keywords
myelodysplastic syndrome,
terminal artery thrombosis,
diagnosis,
local treatment,
surgical tactics,
negative pressure therapy,
autodermoplasty
Supporting agencies: The study had no sponsorship
About the Authors
R. A. Baranov
GBUZ “Morozov Children’s City Clinical Hospital” of the Department of Health of Moscow
Russian Federation
Russian Federation
Baranov Rostislav Anatolyevich – traumatologist-orthopedist, Department of Traumatology and Orthopedics.
1/9 4th Dobryninsky lane, 119049, Moscow
L. А. Latysheva
GBUZ “Morozov Children’s City Clinical Hospital” of the Department of Health of Moscow
Russian Federation
Russian Federation
Latysheva Maria Alekseevna – oncologist, Department of Oncology and Hematology.
1/9 4th Dobryninsky lane, 119049, Moscow
References
1. Afanasyev B. V., Zubarovskaya L. S. Myelodysplastic syndrome in children = Afanas’yev B. V., Zubarovskaya L. S. Miyelodisplasticheskiy sindrom u detey. Rossiyskiy zhurnal detskoy gematologii i onkologii. 2018; 5 (3): 23–35. (In Russ.)
2. Morozova E. V. Myelodysplastic syndrome (classification, diagnosis, treatment): a manual for hematologists, oncologists, general practitioners = Morozova E. V. Miyelodisplasticheskiy sindrom (klassifikatsiya, diagnostika, lecheniye): metodicheskoye posobiye dlya vrachey-gematologov, onkologov, vrachey obshchey praktiki. SPb.: Izd-vo SPbGMU, 2009. 31 s. (In Russ.)
3. Hong M., He G. The 2016 Revision to the World Health Organization Classification of Myelodysplastic Syndromes, J Transl Int Med. 2017; 5 (3): 139–143.
4. Rumyantsev A. G., Maschan M. A., Khachatryan L. A. Federal clinical guidelines for the diagnosis and treatment of myelodysplastic syndrome in children and adolescents = Rumyantsev A. G., Maschan M. A., Khachatryan L. A. Federal’nyye klinicheskiye rekomendatsii po diagnostike i lecheniyu miyelodisplasticheskogo sindroma u detey i podrostkov. M., 2015. 20 s. (In Russ.)
5. Koltunov I. E., Keshishyan R. A., Petrov M. A., et al. Surgical treatment of wound defects in fulminant purpura = Koltunov I. E., Keshishyan R. A., Petrov M. A. i dr. Khirurgicheskoye lecheniye ranevykh defektov pri ful’minantnoy purpure. Rany i ranevyye infektsii. Zhurnal im. prof. B. M. Kostyuchonka. 2017; 4 (2): 24–32. (In Russ.)
6. Adachi M., Mitsuhashi K., Matsuda H., et al. Myelodysplastic syndrome diagnosed on the occasion of Fournier’s gangrene. Rinsho Ketsueki. 2017; 58 (2): 113–118.
7. Mekinian A., Dervin G., Lapidus N., et al. Biologics in Myelodysplastic Syndrome-Related Systemic Inflammatory and Autoimmune Diseases: French Multicenter Retrospective Study of 29 Patients. Autoimmun Rev. 2017; 16 (9): 903–910.
8. Slocum A. M. Y. A surgeon’s nightmare: pyoderma gangrenosum with pathergy effect mimicking necrotising fasciitis. BMJ Case Rep. 2017; 2017: bcr2017222145.
9. Niscola P., Tendas A., Cupelli L., et al. Necrotizing fasciitis in myelodysplastic syndrome: an exceptionally rare occurrence. Support Care Cancer. 2013; 21 (2): 365–366.
Review
For citations:
Baranov R.A., Latysheva L.А. Surgical treatment of necrotizing fasciitis in the myelodysplastic syndrome in a child. Wounds and wound infections. The prof. B.M. Kostyuchenok journal. 2022;9(2):34-43. (In Russ.) https://doi.org/10.25199/2408-9613-2022-9-2-34-43
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