Diagnostic criteria of hepatorenal syndrome and modern methods of therapy (literature review)
https://doi.org/10.17650/2408-9613-2017-4-2-6-11
Abstract
Hepatorenal syndrome (HRS) is a variant of functional renal failure in acute or chronic liver pathology. Type 1 HRS entails a rapidly progressive decline in kidney function within few days and without liver transplantation, 95,0 % of patients die within the next few weeks. With type 2 HRS, kidney function remains stable or gradually declining over several months. HRS diagnosis is based on the exclusion of other causes of renal failure. Pathophysiological changes in renal failure in the case of HRS are quite complex – they include an increase in the synthesis of vasoactive substances, which lead to a decrease in renal perfusion, a decrease in resistance in peripheral arteriovenous anastomosis, the development of portal hypertension, ascites, a decrease in colloidal osmotic pressure and a consistently increasing delay of sodium and water in the kidneys. HRS therapy is based on acid-base balance and anemia correction, intravenous administration of albumin, paracentesis, the removal of nephrotoxic agents and the renal replacement therapy is only symptomatic.
areast-font-family:"Times New Roman";mso-bidi-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA'>, 420012About the Authors
R. R. NagimullinRussian Federation
49 Butlerova St., Kazan, 420012
D. Y. Ustimov
Russian Federation
49 Butlerova St., Kazan, 420012
V. R. Davidova
Russian Federation
49 Butlerova St., Kazan, 420012
F. A. ShipuF. lin
Russian Federation
49 Butlerova St., Kazan, 420012
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Review
For citations:
Nagimullin R.R., Ustimov D.Y., Davidova V.R., ShipuF. lin F.A. Diagnostic criteria of hepatorenal syndrome and modern methods of therapy (literature review). Wounds and wound infections. The prof. B.M. Kostyuchenok journal. 2017;4(2):6-11. (In Russ.) https://doi.org/10.17650/2408-9613-2017-4-2-6-11