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Раны и раневые инфекции. Журнал имени проф. Б.М. Костючёнка

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Системы для контролируемого высвобождения и адресной доставки факторов роста в лечении хронических ран

https://doi.org/10.25199/2408-9613-2018-5-3-6-15

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Аннотация

Факторы роста (ФР) – это эндогенные сигнальные белки, которые регулируют миграцию, пролиферацию и дифференцировку клеток в процессах репарации тканей. Концентрация этих белков в хронических ранах патологически снижена, что приводит к нарушению нормального течения раневого процесса и существенно затрудняет их лечение. В клинической практике используются препараты, содержащие рекомбинантные ФР в свободной форме. Однако их эффективность для лечения хронических ран ограничена, так как в протеолитической среде таких ран ФР подвергаются быстрой деградации. Для преодоления этого недостатка предложены системы для адресной доставки и контролируемого высвобождения на основе биосовместимых материалов: микро- и наночастицы, гидрогели, биопластические материалы. В настоящем обзоре рассмотрены роли ФР в раневом процессе, особенности патофизиологии хронических ран и системы для контролируемого высвобождения и адресной доставки ФР.

Об авторах

А. Р. Липунов
МГУ имени М. В. Ломоносова
Россия
Липунов Артем Ринатович, Химический факультет, Россия, 119234, Москва, ул. Ленинские Горы, д. 1, стр.3


И. М. Афанасов
МГУ имени М. В. Ломоносова
Россия
Химический факультет, Россия, 119234, Москва, ул. Ленинские Горы, д. 1, стр.3


Е. С. Воробьева
ООО «ДжиЭф Групп»
Россия
Россия, 107150, Москва, ул. Бойцовая, д. 22


А. Б. Чухнина
МГУ имени М. В. Ломоносова
Россия
Химический факультет, Россия, 119234, Москва, ул. Ленинские Горы, д. 1, стр.3


М. Г. Гладкова
МГУ имени М. В. Ломоносова
Россия
Факультет биоинженерии и биоинформатики, Россия, 119192, Москва, ул. Ленинские Горы, д. 1 стр. 73


А. В. Кибардин
Федеральное государственное бюджетное учреждение науки «Институт биологии гена» Российской академии наук (ИБГ РАН)
Россия
Россия, 119334, Москва, ул. Вавилова, д. 34/5


В. А. Митиш
ФГБУ «НМИЦ хирургии им. А. В. Вишневского» Минздрава России
Россия
Россия, Большая Серпуховская ул., 27, Москва, 117997


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Для цитирования:


Липунов А.Р., Афанасов И.М., Воробьева Е.С., Чухнина А.Б., Гладкова М.Г., Кибардин А.В., Митиш В.А. Системы для контролируемого высвобождения и адресной доставки факторов роста в лечении хронических ран. Раны и раневые инфекции. Журнал имени проф. Б.М. Костючёнка. 2018;5(3):6-15. https://doi.org/10.25199/2408-9613-2018-5-3-6-15

For citation:


Lipunov A.R., Afanasov I.M., Vorobeva E.S., Chuhnina A.B., Gladkova M.G., Kibardin A.V., Mitish V.A. Molecular systems for targeted delivery and controlled release of growth factors for chronic wound treatment. Wounds and wound infections. The prof. B.M. Kostyuchenok journal. 2018;5(3):6-15. (In Russ.) https://doi.org/10.25199/2408-9613-2018-5-3-6-15

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