ririРаны и раневые инфекции. Журнал имени проф. Б.М. КостючёнкаWounds and wound infections. The prof. B.M. Kostyuchenok journal2408-96132500-0594Regional non-governmental organization “Surgical society - Wounds and wound infections”10.17650/2408-9613-2015-2-2-25-31riri-4Research ArticleОБЗОРЫ, ЛЕКЦИИ, ИСТОРИЯ РАН И РАНЕВЫХ ИНФЕКЦИЙREVIEWS, LECTURES, HISTORY OF WOUNDS AND WOUND INFECTIONSНЕЙТРОФИЛЫ И СИНДРОМ СИСТЕМНОГО ВОСПАЛИТЕЛЬНОГО ОТВЕТАNEUTROPHILS AND SYSTEMIC INFLAMMATORY RESPONSE SYNDROMEГалкинА. А.GalkinA. A.ДемидоваВ. С.DemidovaV. S.demidova@ixv.ruКлинико-диагностический отдел ФГБУ «Институт хирургии им. А. В. Вишневского» Минздрава РоссииРоссияClinical and Diagnostic Department, A. V. Vishnevsky Institute of Surgery, Ministry of Health of RussiaRussian Federation201516122015222531Copyright © Галкин А.А., Демидова В.С., 20152015Галкин А.А., Демидова В.С.Galkin A.A., Demidova V.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.riri.su/jour/article/view/4

В статье обобщены литературные данные о механизмах примирования и активации циркулирующих в кровеносном русле нейтрофилов, адгезионных и неадгезионных механизмах взаимодействия нейтрофилов с эндотелием и описана их роль в возникновении синдрома системного воспалительного ответа. Взаимодействие циркулирующих нейтрофилов с активированным эндотелием – центральное событие в процессе воспаления. Оно включает разнообразные молекулярные события, связанные с адгезией и миграцией нейтрофилов, а также с нарушением проницаемости эндотелия. Одновременная чрезмерная активация эндотелия и нейтрофилов может приводить к повреждениям эндотелия адгезированными нейтрофилами. Цитотоксическое взаимодействие нейтрофилов с эндотелием вносит существенный вклад в патогенез сосудистых и тканевых повреждений при циркуляторных расстройствах и в случае развития синдрома системного воспалительного ответа. Обсуждаются нарушения процессов миграции и фагоцитоза нейтрофилов при синдроме системного воспалительного ответа, связь этих нарушений с примированием и активацией нейтрофилов, а также клиническое значение этих показателей.

The paper summarizes the data available in the literature on the mechanisms responsible for the priming and activation of neutrophils circulating in the blood bed and on the adhesion and nonadhesion mechanisms of neutrophil-endothelium interactions and describes their role in the occurrence of systemic inflammatory response syndrome. The interaction of circulating neutrophils with the activated endothelium is the central event during inflammation. It includes diverse molecular events associated with neutrophil adhesion and migration and with impaired endothelial permeability. The simultaneous overactivation of the endothelium and neutrophils may give rise to endothelial damage caused by adherent neutrophils. The cytotoxic neutrophil-endothelium interaction makes a considerable contribution to the pathogenesis of vascular and tissue injuries in circulatory disturbances and if the systemic inflammatory response syndrome develops. Impaired neutrophil migration and phagocytosis in systemic inflammatory response syndrome, the association of these impairments with neutrophil priming and activation, and the clinical value of these indicators are discussed.

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The authors declare that there are no conflicts of interest present.