ririРаны и раневые инфекции. Журнал имени проф. Б.М. КостючёнкаWounds and wound infections. The prof. B.M. Kostyuchenok journal2408-96132500-0594Regional non-governmental organization “Surgical society - Wounds and wound infections”10.25199/2408-9613-2024-11-2-6-12riri-330Research ArticleОБЗОРЫ, ЛЕКЦИИ, ИСТОРИЯ РАН И РАНЕВЫХ ИНФЕКЦИЙREVIEWS, LECTURES, HISTORY OF WOUNDS AND WOUND INFECTIONSАнализ раневых инфекций при боевой травме в США (обзор литературы)Analysis of wound infections in combat injuries in US (a literature review)https://orcid.org/0000-0002-7851-3813БорисовИ. В.BorisovI. V.

Борисов Игорь Викторович – доктор медицинских наук, заведующий кабинетом диабетической стопы отдела ран и раневых инфекций; доцент кафедры медицины катастроф

117997, Москва, ул. Большая Серпуховская, д. 27;

117198, Москва, ул. Миклухо-Маклая, д. 8

Igor V. Borisov – MD, Dr. Sc. (Med.), Head of Diabetic Foot Office in Wounds and Wound Infections Department; Associate Professor at the Department

27 Bolshaya Serpukhovskaya Str., Moscow, 117997;

8 Miklukho-Maklaya Str., Moscow, 117198

boris-62@list.ruhttps://orcid.org/0000-0001-6411-0709МитишВ. А.MitishV. A.

Митиш Валерий Афанасьевич – кандидат медицинских наук, доцент, заведующий отделом ран и раневых инфекций; заведующий кафедрой медицины катастроф 

117997, Москва, ул. Большая Серпуховская, д. 27;

117198, Москва, ул. Миклухо-Маклая, д. 8

Valery A. Mitish – MD, Cand. Sci. (Med.), Associate Professor, Head of the Department of Wounds and Wound Infections; Head of the Department of Disaster Medicine

27 Bolshaya Serpukhovskaya Str., Moscow, 117997;

8 Miklukho-Maklaya Str., Moscow, 117198

https://orcid.org/0000-0003-1215-8035ПасхаловаЮ. С.PaskhalovaYu. S.

Пасхалова Юлия Сергеевна – кандидат медицинских наук, старший научный сотрудник отдела ран и раневых инфекций; доцент кафедры медицины катастроф

117997, Москва, ул. Большая Серпуховская, д. 27;

117198, Москва, ул. Миклухо-Маклая, д. 8

Yulia S. Paskhalova – MD, Cand. Sci. (Med.), Senior Researcher at the Department of Wounds and Wound Infections; Associate Professor of the Department of Disaster Medicine

27 Bolshaya Serpukhovskaya Str., Moscow, 117997;

8 Miklukho-Maklaya Str., Moscow, 117198

ФГБУ «Национальный медицинский исследовательский центр хирургии им. А. В. Вишневского» Минздрава России; ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы» Минобрнауки РоссииРоссияA. V. Vishnevsky National Medical Research Center of Surgery; Patrice Lumumba Peoples’ Friendship University of RussiaRussian Federation202423102024112612Copyright © Борисов И.В., Митиш В.А., Пасхалова Ю.С., 20242024Борисов И.В., Митиш В.А., Пасхалова Ю.С.Borisov I.V., Mitish V.A., Paskhalova Y.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.riri.su/jour/article/view/330

В статье описаны проблемы, с которыми столкнулись военные медики при оказании медицинской помощи военнослужащим, участвовавшим в вооруженных конфликтах на территории Ирака и Афганистана. Представлены результаты и достижения многоцентрового исследования инфекционных последствий травм TIDOS (The Trauma Infectious Diseases Outcomes Study) Министерства обороны США (DoD) и Министерства по делам ветеранов (VA) в рамках Программы клинических исследований инфекционных заболеваний USU (IDCRP). Также обсуждаются возможные направления будущих исследований и их актуальность.

The article describes problems faced by military doctors in providing medical care to military personnel who had participated in armed conflicts in Iraq and Afghanistan. The authors also discuss results and achievements of multicenter study on consequences of infected wounds TIDOS (The Trauma Infectious Diseases Outcomes Study) of the U.S. Department of Defense (DoD) and the Department of Veterans Affairs (VA) within the program of clinical researches on infectious diseases (USU Infectious Diseases Clinical Research Program – IDCRP). Possible directions for further researches and their importance are also discussed.

боевые травмыраныраневая инфекциягнойная ранагнойно-некротический очагхирургическая инфекциядиагностикадифференциальная диагностикахирургическое лечениеместное лечениеcombat injurieswoundswound infectionpurulent woundpurulent necrotic focussurgical infectiondiagnosisdifferential diagnosissurgical treatmentlocal treatmentИсследование не имело спонсорской поддержкиThe study had no sponsorshipReferencesEastridge B. J., Jenkins D., Flaherty S., et al. Trauma system development in a theater of war: experiences from Operation Iraqi Freedom and Operation Enduring Freedom. J Trauma. 2006; 61 (6):1366–1372, discussion 72–73.Eastridge B. J., Jenkins D., Flaherty S., et al. Trauma system development in a theater of war: experiences from Operation Iraqi Freedom and Operation Enduring Freedom. J Trauma. 2006; 61 (6):1366–1372, discussion 72–73.Weintrob A. C., Murray C. K., Xu J., et al. Early Infections Complicating the Care of Combat Casualties from Iraq and Afghanistan. Surg Infect (Larchmt). 2018; 19 (3): 286–297.Weintrob A. C., Murray C. K., Xu J., et al. Early Infections Complicating the Care of Combat Casualties from Iraq and Afghanistan. Surg Infect (Larchmt). 2018; 19 (3): 286–297.Tribble D. R., Li P., Warkentien T. E., et al. Impact of operational theater on combat and noncombat trauma-related infections. Mil Med. 2016; 181 (10): 1258–1268.Tribble D. R., Li P., Warkentien T. E., et al. Impact of operational theater on combat and noncombat trauma-related infections. Mil Med. 2016; 181 (10): 1258–1268.Nessen S. C., Gurney J., Rasmussen T. E., et al. Unrealized potential of the US military battlefield trauma system: DOW rate is higher in Iraq and Afghanistan than in Vietnam, but CFR and KIA rate are lower. J Trauma Acute Care Surg. 2018; 85 (1S): S4–S12.Nessen S. C., Gurney J., Rasmussen T. E., et al. Unrealized potential of the US military battlefield trauma system: DOW rate is higher in Iraq and Afghanistan than in Vietnam, but CFR and KIA rate are lower. J Trauma Acute Care Surg. 2018; 85 (1S): S4–S12.Petfield J. L., Lewandowski L. R., Stewart L., et al. IDCRP Combat-Related Extremity Wound Infection Research. Mil Med. 2022; 187 (Suppl 2): 25–33.Petfield J. L., Lewandowski L. R., Stewart L., et al. IDCRP Combat-Related Extremity Wound Infection Research. Mil Med. 2022; 187 (Suppl 2): 25–33.McDonald J., Liang S. Y., Li P., et al. DoD-VA trauma infection research collaboration. Mil Med. 2022; 187 (Suppl 2): 17– 24.McDonald J., Liang S. Y., Li P., et al. DoD-VA trauma infection research collaboration. Mil Med. 2022; 187 (Suppl 2): 17– 24.Tribble D. R., Murray C. K., Lloyd B. A., et al. After the Battlefield: Infectious Complications among Wounded Warriors in the Trauma Infectious Disease Outcomes Study. Mil Med. 2019; 184 (Suppl 2): 18–25.Tribble D. R., Murray C. K., Lloyd B. A., et al. After the Battlefield: Infectious Complications among Wounded Warriors in the Trauma Infectious Disease Outcomes Study. Mil Med. 2019; 184 (Suppl 2): 18–25.Lewandowski L. R., Potter B. K., Murray C. K., et al. Osteomyelitis risk factors related to combat trauma open femur fractures: a case-control analysis. J Orthop Trauma. 2019; 33 (4): e110–e119.Lewandowski L. R., Potter B. K., Murray C. K., et al. Osteomyelitis risk factors related to combat trauma open femur fractures: a case-control analysis. J Orthop Trauma. 2019; 33 (4): e110–e119.Tribble D. R., Lewandowski L. R., Potter B. K., et al. Osteomyelitis risk factors related to combat trauma open tibia fractures: a case-controlanalysis. J Orthop Trauma. 2018; 32 (9): e344–e353.Tribble D. R., Lewandowski L. R., Potter B. K., et al. Osteomyelitis risk factors related to combat trauma open tibia fractures: a case-controlanalysis. J Orthop Trauma. 2018; 32 (9): e344–e353.Warkentien T. E., Lewandowski L. R., Potter B. K., et al. Osteomyelitis risk factors related to combat trauma open upper extremity fractures: a case-control analysis. J Orthop Trauma. 2019; 33 (12): e475–e483.Warkentien T. E., Lewandowski L. R., Potter B. K., et al. Osteomyelitis risk factors related to combat trauma open upper extremity fractures: a case-control analysis. J Orthop Trauma. 2019; 33 (12): e475–e483.Stewart L., Shaikh F., Bradley W., et al. Combat-related extremity wounds: injury factors predicting early onset infections. Mil Med. 2019; 184 (Suppl 1): 83–91.Stewart L., Shaikh F., Bradley W., et al. Combat-related extremity wounds: injury factors predicting early onset infections. Mil Med. 2019; 184 (Suppl 1): 83–91.Stewart L., Li P., Blyth D. M., et al. Antibiotic practice patterns for extremity wound infections among blast-injured subjects. Mil Med. 2020; 185 (Suppl 1): 628–636.Stewart L., Li P., Blyth D. M., et al. Antibiotic practice patterns for extremity wound infections among blast-injured subjects. Mil Med. 2020; 185 (Suppl 1): 628–636.Lloyd B. A., Murray C. K., Shaikh F., et al. Early infectious outcomes after addition of fluoroquinolone or aminoglycoside to posttrauma antibiotic prophylaxis in combat-related open fracture injuries. J Trauma Acute Care Surg. 2017; 83 (5): 854–861.Lloyd B. A., Murray C. K., Shaikh F., et al. Early infectious outcomes after addition of fluoroquinolone or aminoglycoside to posttrauma antibiotic prophylaxis in combat-related open fracture injuries. J Trauma Acute Care Surg. 2017; 83 (5): 854–861.Lloyd B. A., Murray C. K., Bradley W., et al. Variation in postinjury antibiotic prophylaxis patterns over five years in a combat zone. Mil Med. 2017; 182 (S1): 346–352.Lloyd B. A., Murray C. K., Bradley W., et al. Variation in postinjury antibiotic prophylaxis patterns over five years in a combat zone. Mil Med. 2017; 182 (S1): 346–352.Warkentien T. E., Shaikh F., Weintrob A. C., et al. Impact of Mucorales and Other Invasive Molds on Clinical Outcomes of Polymicrobial Traumatic Wound Infections J Clin Microbiol. 2015; 53 (7): 2262–2270.Warkentien T. E., Shaikh F., Weintrob A. C., et al. Impact of Mucorales and Other Invasive Molds on Clinical Outcomes of Polymicrobial Traumatic Wound Infections J Clin Microbiol. 2015; 53 (7): 2262–2270.Weintrob A. C., Weisbrod A. B., Dunne J. R., et al. Combat trauma associated invasive fungal wound infections: Epidemiology and clinical classification. Epidemiol Infect. 2015; 143 (1): 214–224.Weintrob A. C., Weisbrod A. B., Dunne J. R., et al. Combat trauma associated invasive fungal wound infections: Epidemiology and clinical classification. Epidemiol Infect. 2015; 143 (1): 214–224.Lundy J. B., Driscoll I.R. Experience with proctectomy to manage combat casualties sustaining catastrophic perineal blast injury complicated by invasive mucor softtissue infections. Mil Med. 2014; 179 (3): e347–e350.Lundy J. B., Driscoll I.R. Experience with proctectomy to manage combat casualties sustaining catastrophic perineal blast injury complicated by invasive mucor softtissue infections. Mil Med. 2014; 179 (3): e347–e350.Lewandowski L. R., Weintrob A. C., Tribble D. R., et al. Early complications and outcomes in combat injury related invasive fungal wound infections: a case-control analysis. J Orthop Trauma. 2016; 30 (3):. e93–e99.Lewandowski L. R., Weintrob A. C., Tribble D. R., et al. Early complications and outcomes in combat injury related invasive fungal wound infections: a case-control analysis. J Orthop Trauma. 2016; 30 (3):. e93–e99.Ganesan A., Wells J., Shaikh F., et al. Molecular detection of filamentous fungi in formalin-fixed paraffin-embedded specimens in invasive fungal wound infections is feasible with high specificity. J Clin Microbiol. 2020; 58 (1): e01259-19.Ganesan A., Wells J., Shaikh F., et al. Molecular detection of filamentous fungi in formalin-fixed paraffin-embedded specimens in invasive fungal wound infections is feasible with high specificity. J Clin Microbiol. 2020; 58 (1): e01259-19.Rodriguez C. J., Ganesan A., Shaikh F., et al. Combat-related invasive fungal wound infections. Mil Med. 2022; 187 (Suppl 2): 34–41.Rodriguez C. J., Ganesan A., Shaikh F., et al. Combat-related invasive fungal wound infections. Mil Med. 2022; 187 (Suppl 2): 34–41.Mende K., Akers K. S., Tyner S., et al. Multidrug-Resistant and Virulent Organisms (MDR/VO) trauma infections: TIDOS initiative. Mil Med. 2022; 187 (Suppl 2): 42–51.Mende K., Akers K. S., Tyner S., et al. Multidrug-Resistant and Virulent Organisms (MDR/VO) trauma infections: TIDOS initiative. Mil Med. 2022; 187 (Suppl 2): 42–51.Gilbert L. J., Li P., Murray C. K., et al. Multidrug-resistant gram-negative bacilli colonization risk factors among trauma patients. Diagn Microbiol Infect Dis. 2016; 84 (4): 358–360.Gilbert L. J., Li P., Murray C. K., et al. Multidrug-resistant gram-negative bacilli colonization risk factors among trauma patients. Diagn Microbiol Infect Dis. 2016; 84 (4): 358–360.Mende K., Beckius M. L., Zera W. C., et al. Lack of doxycycline antimalarial prophylaxis impact on Staphylococcus aureus tetracycline resistance. Diagn Microbiol Infect Dis. 2016; 86 (2): 211–220.Mende K., Beckius M. L., Zera W. C., et al. Lack of doxycycline antimalarial prophylaxis impact on Staphylococcus aureus tetracycline resistance. Diagn Microbiol Infect Dis. 2016; 86 (2): 211–220.Campbell W. R., Li P., Whitman T. J., et al. Multi-drug–resistant gram negative infections in deployment-related trauma patients. Surg Infect. 2017; 18 (3): 357–367.Campbell W. R., Li P., Whitman T. J., et al. Multi-drug–resistant gram negative infections in deployment-related trauma patients. Surg Infect. 2017; 18 (3): 357–367.Heitkamp R. A., Li P., Mende K., et al. Association of Enterococcus spp. with severe combat extremity injury, intensive care, and polymicrobial wound infection. Surg Infect. 2018; 19 (1): 95–103.Heitkamp R. A., Li P., Mende K., et al. Association of Enterococcus spp. with severe combat extremity injury, intensive care, and polymicrobial wound infection. Surg Infect. 2018; 19 (1): 95–103.Mende K., Stewart L., Shaikh F. Microbiology of combat-related extremity wounds: Trauma Infectious Disease Outcomes Study. Diagn Microbiol Infect Dis. 2019; 94 (2): 173–179.Mende K., Stewart L., Shaikh F. Microbiology of combat-related extremity wounds: Trauma Infectious Disease Outcomes Study. Diagn Microbiol Infect Dis. 2019; 94 (2): 173–179.McDonald J. R., Liang S. Y., Li P., et al. Infectious complications after deployment trauma: following wounded United States military personnel into Veterans Affairs care. Clin Infect Dis. 2018; 67 (8): 1205–1212.McDonald J. R., Liang S. Y., Li P., et al. Infectious complications after deployment trauma: following wounded United States military personnel into Veterans Affairs care. Clin Infect Dis. 2018; 67 (8): 1205–1212.Petfield J. L., Tribble D. R., Potter B. K., et al. Is bone loss or devascularization associated with recurrence of osteomyelitis in wartime open tibia fractures? Clin Orthop Relat Res. 2019; 477 (4): 789–801.Petfield J. L., Tribble D. R., Potter B. K., et al. Is bone loss or devascularization associated with recurrence of osteomyelitis in wartime open tibia fractures? Clin Orthop Relat Res. 2019; 477 (4): 789–801.Liang S. Y., Jackson B., Kuhn J., et al. Urinary tract infections after combat-related genitourinary trauma. Surg Infect. 2019; 20 (8): 611–618.Liang S. Y., Jackson B., Kuhn J., et al. Urinary tract infections after combat-related genitourinary trauma. Surg Infect. 2019; 20 (8): 611–618.Saeed O., Tribble D., Biever K., et al. Infection prevention in combat-related injuries. Mil Med. 2018; 183 (Suppl_2): 137– 141.Saeed O., Tribble D., Biever K., et al. Infection prevention in combat-related injuries. Mil Med. 2018; 183 (Suppl_2): 137– 141.Lewis C. J., Li P., Stewart L., et al. Tranexamic acid in life-threatening military injury and the associated risk of infective complications. Br J Surg. 2016; 103 (4): 366–373.Lewis C. J., Li P., Stewart L., et al. Tranexamic acid in life-threatening military injury and the associated risk of infective complications. Br J Surg. 2016; 103 (4): 366–373.Bozzay J. D., Walker P. F., Schechtman D. W., et al. Outcomes of exploratory laparotomy and abdominal infections among combat casualties. J Surg Res. 2021; 257 (1): 285–293.Bozzay J. D., Walker P. F., Schechtman D. W., et al. Outcomes of exploratory laparotomy and abdominal infections among combat casualties. J Surg Res. 2021; 257 (1): 285–293.Yabes J. M., Stewart L., Shaikh F., et al. Risk of acute kidney injury in combatinjured patients associated with concomitant vancomycin and extended-spectrum β-lactam antibiotic use. J Intensive Care Med. 2021; 36 (7): 818–827.Yabes J. M., Stewart L., Shaikh F., et al. Risk of acute kidney injury in combatinjured patients associated with concomitant vancomycin and extended-spectrum β-lactam antibiotic use. J Intensive Care Med. 2021; 36 (7): 818–827.Tribble D. R. IDCRP Trauma-Related Infection Research. Mil Med. 2022; 187 (Suppl 2): 2–6.Tribble D. R. IDCRP Trauma-Related Infection Research. Mil Med. 2022; 187 (Suppl 2): 2–6.

The authors declare that there are no conflicts of interest present.