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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">riri</journal-id><journal-title-group><journal-title xml:lang="ru">Раны и раневые инфекции. Журнал имени проф. Б.М. Костючёнка</journal-title><trans-title-group xml:lang="en"><trans-title>Wounds and wound infections. The prof. B.M. Kostyuchenok journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2408-9613</issn><issn pub-type="epub">2500-0594</issn><publisher><publisher-name>Regional non-governmental organization “Surgical society - Wounds and wound infections”</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">riri-14</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>ИСПОЛЬЗОВАНИЕ БИОМАРКЕРА ПРЕСЕПСИН ДЛЯ РАННЕЙ И ВЫСОКОСПЕЦИФИЧНОЙ ДИАГНОСТИКИ СЕПСИСА</article-title><trans-title-group xml:lang="en"><trans-title>USE OF THE BIOMARKER PRESEPSIN FOR THE EARLY AND HIGHLY SPECIFIC DIAGNOSIS OF SEPSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вельков</surname><given-names>В. В.</given-names></name></name-alternatives><email xlink:type="simple">vvv@diakonlab.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>17</day><month>12</month><year>2015</year></pub-date><volume>2</volume><issue>1</issue><fpage>53</fpage><lpage>82</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Вельков В.В., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Вельков В.В.</copyright-holder><copyright-holder xml:lang="en">Вельков В.В.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.riri.su/jour/article/view/14">https://www.riri.su/jour/article/view/14</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Moore L. J., Moore F. A., Todd S. R. et al. Sepsis in general surgery: the 2005–2007 national surgical quality improvement program perspective. Arch Surg 2010;145(7):695–700.</mixed-citation><mixed-citation xml:lang="en">Moore L. J., Moore F. A., Todd S. R. et al. Sepsis in general surgery: the 2005–2007 national surgical quality improvement program perspective. Arch Surg 2010;145(7):695–700.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar G., Kumar N., Taneja A. Nationwide trends of severe sepsis in the 21st century (2000–2007). Chest 2011;140(5):1223–31.</mixed-citation><mixed-citation xml:lang="en">Kumar G., Kumar N., Taneja A. Nationwide trends of severe sepsis in the 21st century (2000–2007). Chest 2011;140(5):1223–31.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Lagu T., Rothberg M. B., Shieh M. S. et al. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med 2012;40(3):754–61.</mixed-citation><mixed-citation xml:lang="en">Lagu T., Rothberg M. B., Shieh M. S. et al. Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007. Crit Care Med 2012;40(3):754–61.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Namas R., Zamora R., Namas R. et al. Sepsis: Something old, something new, and a systems view. J Crit Care 2012;27(3):314. e1–11.</mixed-citation><mixed-citation xml:lang="en">Namas R., Zamora R., Namas R. et al. Sepsis: Something old, something new, and a systems view. J Crit Care 2012;27(3):314. e1–11.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mayr F. B., Yende S., Angus D. C. Epidemiology of severe sepsis. Virulence 2014;5(1):4–11.</mixed-citation><mixed-citation xml:lang="en">Mayr F. B., Yende S., Angus D. C. Epidemiology of severe sepsis. Virulence 2014;5(1):4–11.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Horeczko T., Green J. P., Panacek E. A. Epidemiology of the systemic inflammatory response syndrome (SIRS) in the Emergency Department. West J Emerg Med 2014;15(3):329–36.</mixed-citation><mixed-citation xml:lang="en">Horeczko T., Green J. P., Panacek E. A. Epidemiology of the systemic inflammatory response syndrome (SIRS) in the Emergency Department. West J Emerg Med 2014;15(3):329–36.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Angus D. C., Linde-Zwirble W. T., Lidicker J. et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29(7):1303–10.</mixed-citation><mixed-citation xml:lang="en">Angus D. C., Linde-Zwirble W. T., Lidicker J. et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29(7):1303–10.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Moore L. J., Moore F. A. Early diagnosis and evidence-based care of surgical sepsis. J Intensive Care Med 2013;28(2):107–17.</mixed-citation><mixed-citation xml:lang="en">Moore L. J., Moore F. A. Early diagnosis and evidence-based care of surgical sepsis. J Intensive Care Med 2013;28(2):107–17.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hartman M. E., Linde-Zwirble W. T. Angus D. C., Watson R. S. Trends in the epidemiology of pediatric severe sepsis. Pediatr Crit Care Med 2013;14(7):686–93.</mixed-citation><mixed-citation xml:lang="en">Hartman M. E., Linde-Zwirble W. T. Angus D. C., Watson R. S. Trends in the epidemiology of pediatric severe sepsis. Pediatr Crit Care Med 2013;14(7):686–93.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar A., Roberts D., Wood K. E. et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34(6):1589–96.</mixed-citation><mixed-citation xml:lang="en">Kumar A., Roberts D., Wood K. E. et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34(6):1589–96.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar A., Ellis P., Arabi Y. et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009;136(5):1237–48.</mixed-citation><mixed-citation xml:lang="en">Kumar A., Ellis P., Arabi Y. et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009;136(5):1237–48.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Marshall J. C., Reinhart K.; International Sepsis Forum. Biomarkers of sepsis. Crit Care Med 2009;37(7):2290–8.</mixed-citation><mixed-citation xml:lang="en">Marshall J. C., Reinhart K.; International Sepsis Forum. Biomarkers of sepsis. Crit Care Med 2009;37(7):2290–8.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pierrakos C, Vincent J. L. Sepsis biomarkers: a review. Crit Care 2010;14(1):R15.</mixed-citation><mixed-citation xml:lang="en">Pierrakos C, Vincent J. L. Sepsis biomarkers: a review. Crit Care 2010;14(1):R15.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Samraj R. S., Zingarelli B., Wong H. R. Role of biomarkers in sepsis care. Shock 2013;40(5):358–65.</mixed-citation><mixed-citation xml:lang="en">Samraj R. S., Zingarelli B., Wong H. R. Role of biomarkers in sepsis care. Shock 2013;40(5):358–65.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Reinhart K., Meisner M. Biomarkers in the critically ill patient: procalcitonin. Crit Care Clin 2011;27(2):253–63.</mixed-citation><mixed-citation xml:lang="en">Reinhart K., Meisner M. Biomarkers in the critically ill patient: procalcitonin. Crit Care Clin 2011;27(2):253–63.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Vincent J. L., Donadello K., Schmit X. Biomarkers in the critically ill patient: C-reactive protein. Crit Care Clin 2011;27(2):241–51.</mixed-citation><mixed-citation xml:lang="en">Vincent J. L., Donadello K., Schmit X. Biomarkers in the critically ill patient: C-reactive protein. Crit Care Clin 2011;27(2):241–51.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Christ-Crain M., Muller B. Procalcitonin in bacterial infections – hype, hope, more or less? Swiss Med Wkly 2005; 135(31–32):451–60.</mixed-citation><mixed-citation xml:lang="en">Christ-Crain M., Muller B. Procalcitonin in bacterial infections – hype, hope, more or less? Swiss Med Wkly 2005; 135(31–32):451–60.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Вельков В. В. Прокальцитонин и С-реактивный белок в современной лабораторной диагностике. Часть 1. Клинико-лабораторный консилиум. 2008;6(25):46–52. [Velkov V. V. Procalcitonin and C-reactive protein in the state-of-art laboratory diagnostics. Part 1. Klinikolaboratornyi konsilium = Clinical and Laboratory Consultation. 2008;6(25):46–52. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Вельков В. В. Прокальцитонин и С-реактивный белок в современной лабораторной диагностике. Часть 1. Клинико-лабораторный консилиум. 2008;6(25):46–52. [Velkov V. V. Procalcitonin and C-reactive protein in the state-of-art laboratory diagnostics. Part 1. Klinikolaboratornyi konsilium = Clinical and Laboratory Consultation. 2008;6(25):46–52. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Вельков В. В. Прокальцитонин и С-реактивный белок в современной лабораторной диагностике. Часть 2. Клинико-лабораторный консилиум. 2009;1(26):34–48. [Velkov V. V. Procalcitonin and C-reactive protein in the state-of-art laboratory diagnostics. Part 2. Klinikolaboratornyi konsilium = Clinical and Laboratory Consultation. 2009;1(26):34–48 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Вельков В. В. Прокальцитонин и С-реактивный белок в современной лабораторной диагностике. Часть 2. Клинико-лабораторный консилиум. 2009;1(26):34–48. [Velkov V. V. Procalcitonin and C-reactive protein in the state-of-art laboratory diagnostics. Part 2. Klinikolaboratornyi konsilium = Clinical and Laboratory Consultation. 2009;1(26):34–48 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ingram N. Procalcitonin: does it have a role in the diagnosis, management and prognosis of patients with sepsis? JICS 2013;14(3):226–30.</mixed-citation><mixed-citation xml:lang="en">Ingram N. Procalcitonin: does it have a role in the diagnosis, management and prognosis of patients with sepsis? JICS 2013;14(3):226–30.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Biller K., Fae F., Germann R. et al. How reliable is procalcitonin as an inflammatory marker? Laboratoriums Medizin 2012;35(6):1–6.</mixed-citation><mixed-citation xml:lang="en">Biller K., Fae F., Germann R. et al. How reliable is procalcitonin as an inflammatory marker? Laboratoriums Medizin 2012;35(6):1–6.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Meisner M. Update on procalcitonin measurements. Ann Lab Med 2014;34(4):263–73.</mixed-citation><mixed-citation xml:lang="en">Meisner M. Update on procalcitonin measurements. Ann Lab Med 2014;34(4):263–73.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sridharan P., Chamberlain R. S. The efficacy of procalcitonin as a biomarker in the management of sepsis: slaying dragons or tilting at windmills? Surg Infect (Larchmt) 2013;14(6):489–511.</mixed-citation><mixed-citation xml:lang="en">Sridharan P., Chamberlain R. S. The efficacy of procalcitonin as a biomarker in the management of sepsis: slaying dragons or tilting at windmills? Surg Infect (Larchmt) 2013;14(6):489–511.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Yaegashi Y., Shirakawa K., Sato N. et al. Evaluation of a newly identified soluble CD14 subtype as a marker for sepsis. J Infect Chemother 2005;11(5):234–8.</mixed-citation><mixed-citation xml:lang="en">Yaegashi Y., Shirakawa K., Sato N. et al. Evaluation of a newly identified soluble CD14 subtype as a marker for sepsis. J Infect Chemother 2005;11(5):234–8.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Endo S., Takahashi G., Shozushima T. et al. Usefulness of presepsin (soluble CD14 subtype) as a diagnostic marker for sepsis. JAAM 2012;23:27–38.</mixed-citation><mixed-citation xml:lang="en">Endo S., Takahashi G., Shozushima T. et al. Usefulness of presepsin (soluble CD14 subtype) as a diagnostic marker for sepsis. JAAM 2012;23:27–38.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Вельков В. В. Пресепсин – новый высокоэффективный биомаркер сепсиса. Клинико-лабораторный консилиум. 2012;2(42):56–62. [Velkov V. V. Presepsin as a new highly efficient sepsis biomarker. Kliniko-laboratornyi konsilium = Clinical and laboratory consultation. 2012;2(42):56–62. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Вельков В. В. Пресепсин – новый высокоэффективный биомаркер сепсиса. Клинико-лабораторный консилиум. 2012;2(42):56–62. [Velkov V. V. Presepsin as a new highly efficient sepsis biomarker. Kliniko-laboratornyi konsilium = Clinical and laboratory consultation. 2012;2(42):56–62. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Agilli M., Sener I., Yesildal F. et al. A new marker for the diagnosis of sepsis: Presepsin. J Investig Biochem 2012;1(1):55–7.</mixed-citation><mixed-citation xml:lang="en">Agilli M., Sener I., Yesildal F. et al. A new marker for the diagnosis of sepsis: Presepsin. J Investig Biochem 2012;1(1):55–7.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Faix J. D. Presepsin – the new kid on the sepsis block. Clin Biochem 2014;47(7–8):503–4.</mixed-citation><mixed-citation xml:lang="en">Faix J. D. Presepsin – the new kid on the sepsis block. Clin Biochem 2014;47(7–8):503–4.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Pizzolato E., Ulla M., Galluzzo C. et al. Role of presepsin for the evaluation of sepsis in the emergency department. Clin Chem Lab Med 2014;52(10):1395–400.</mixed-citation><mixed-citation xml:lang="en">Pizzolato E., Ulla M., Galluzzo C. et al. Role of presepsin for the evaluation of sepsis in the emergency department. Clin Chem Lab Med 2014;52(10):1395–400.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Zou Q., Wen W., Zhang X. Presepsin as a novel sepsis biomarker. World J Emerg Med 2014;5(1):16–9.</mixed-citation><mixed-citation xml:lang="en">Zou Q., Wen W., Zhang X. Presepsin as a novel sepsis biomarker. World J Emerg Med 2014;5(1):16–9.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Окамура И., Томэ Р. Пресепсин: новый биомаркер для прогнозирования и диагностики сепсиса. Лаборатория 2014;(1):9–10. [Okamura I., Tome R. Presepsin: a new biomarker for forecasting and diagnostics of sepsis. Laboratoriya = Laboratory 2014;(1):9–10. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Окамура И., Томэ Р. Пресепсин: новый биомаркер для прогнозирования и диагностики сепсиса. Лаборатория 2014;(1):9–10. [Okamura I., Tome R. Presepsin: a new biomarker for forecasting and diagnostics of sepsis. Laboratoriya = Laboratory 2014;(1):9–10. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Antal-Szalmaґs P. Evaluation of CD14 in host defense. Eur J Clin Invest 2000;30(2):167–79.</mixed-citation><mixed-citation xml:lang="en">Antal-Szalmaґs P. Evaluation of CD14 in host defense. Eur J Clin Invest 2000;30(2):167–79.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Bas S., Gauthier B. R., Spenato U. et al. CD14 is an acute phase protein. J Immunol 2004;172(7):4470–9.</mixed-citation><mixed-citation xml:lang="en">Bas S., Gauthier B. R., Spenato U. et al. CD14 is an acute phase protein. J Immunol 2004;172(7):4470–9.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Savedra R. Jr, Delude R. L., Ingalls R. R. et al. Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system. J Immunol 1996;157(6):2549–54.</mixed-citation><mixed-citation xml:lang="en">Savedra R. Jr, Delude R. L., Ingalls R. R. et al. Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system. J Immunol 1996;157(6):2549–54.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sellati T. J., Bouis D. A., Kitchens R. L. et al. Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide. J Immunol 1998;160(11):5455–64.</mixed-citation><mixed-citation xml:lang="en">Sellati T. J., Bouis D. A., Kitchens R. L. et al. Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide. J Immunol 1998;160(11):5455–64.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Dziarski R., Tapping R. I., Tobias P. S. Binding of bacterial peptidoglycan to CD14. J Biol Chem 1998;273(15):8680–90.</mixed-citation><mixed-citation xml:lang="en">Dziarski R., Tapping R. I., Tobias P. S. Binding of bacterial peptidoglycan to CD14. J Biol Chem 1998;273(15):8680–90.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Klein B. S. Role of cell surface molecules of Blastomyces dermatidis in the pathogenesis and immunobiology of blastomycosis. Semin Respir Infect 1997;12(3):198–205.</mixed-citation><mixed-citation xml:lang="en">Klein B. S. Role of cell surface molecules of Blastomyces dermatidis in the pathogenesis and immunobiology of blastomycosis. Semin Respir Infect 1997;12(3):198–205.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Hailman E., Lichenstein H. S., Wurfel M. M. et al. Lipopolysaccharide (LPS) binding protein accelerates the binding of LPS to CD14. J Exp Med 1994;179(1):269–76.</mixed-citation><mixed-citation xml:lang="en">Hailman E., Lichenstein H. S., Wurfel M. M. et al. Lipopolysaccharide (LPS) binding protein accelerates the binding of LPS to CD14. J Exp Med 1994;179(1):269–76.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Fan X., Stelter F., Menzel R. Structures in Bacillus subtilis are recognized by CD14 ina lipopolysaccharide binding protein-dependent reaction. Infect Immun 1999;67(6):2964–8.</mixed-citation><mixed-citation xml:lang="en">Fan X., Stelter F., Menzel R. Structures in Bacillus subtilis are recognized by CD14 ina lipopolysaccharide binding protein-dependent reaction. Infect Immun 1999;67(6):2964–8.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Hasebe A., Mu H. H., Washburn L. R. Inflammatory lipoproteins purified from a toxigenic and arthritogenic strain of Mycoplasma arthritidis are dependent on Toll-like receptor 2 and CD14. Infect Immun 2007;75(4):1820–6.</mixed-citation><mixed-citation xml:lang="en">Hasebe A., Mu H. H., Washburn L. R. Inflammatory lipoproteins purified from a toxigenic and arthritogenic strain of Mycoplasma arthritidis are dependent on Toll-like receptor 2 and CD14. Infect Immun 2007;75(4):1820–6.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Grunwald U., Krüger C., Westermann J. et al. An enzyme-linked immunosorbent assay for the quantification of solubilized CD14</mixed-citation><mixed-citation xml:lang="en">Grunwald U., Krüger C., Westermann J. et al. An enzyme-linked immunosorbent assay for the quantification of solubilized CD14</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">in biological fluids. J Immunol Methods 1992;155(2):225–32.</mixed-citation><mixed-citation xml:lang="en">in biological fluids. J Immunol Methods 1992;155(2):225–32.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Shirakawa K., Naitou K., Hirose J. et al. The new sepsis marker, sCD14-ST, induction mechanism in the rabbit sepsis models. Crit Care 2010;14(Suppl 2):19.</mixed-citation><mixed-citation xml:lang="en">Shirakawa K., Naitou K., Hirose J. et al. The new sepsis marker, sCD14-ST, induction mechanism in the rabbit sepsis models. Crit Care 2010;14(Suppl 2):19.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Dandona P., Nix D., Wilson M. F. et al. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994;79(6):1605–8.</mixed-citation><mixed-citation xml:lang="en">Dandona P., Nix D., Wilson M. F. et al. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994;79(6):1605–8.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Endo S., Suzuki Y., Takahashi G. et al. Presepsin as a powerful monitoring tool for the prognosis and treatment of sepsis:</mixed-citation><mixed-citation xml:lang="en">Endo S., Suzuki Y., Takahashi G. et al. Presepsin as a powerful monitoring tool for the prognosis and treatment of sepsis:</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">A multicenter prospective study. J Infect Chemother 2013;18(6):891–7.</mixed-citation><mixed-citation xml:lang="en">A multicenter prospective study. J Infect Chemother 2013;18(6):891–7.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Fukui Y., Okamura Y. Clinical performance of a point-of-care assay for measurement of presepsin in patients with bacteremia. Crit Care 2013;17(Suppl 4):58.</mixed-citation><mixed-citation xml:lang="en">Fukui Y., Okamura Y. Clinical performance of a point-of-care assay for measurement of presepsin in patients with bacteremia. Crit Care 2013;17(Suppl 4):58.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Shozushima T., Takahashi G., Matsumoto N. et al. Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J Infect Chemother 2011;17(6):764–9.</mixed-citation><mixed-citation xml:lang="en">Shozushima T., Takahashi G., Matsumoto N. et al. Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis that satisfied diagnostic criteria of systemic inflammatory response syndrome. J Infect Chemother 2011;17(6):764–9.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Liu B., Chen Y. X., Yin Q. et al. Diagnostic value and prognostic evaluation of Presepsin for sepsis in an emergency department. Crit Care 2013;17(5):R244.</mixed-citation><mixed-citation xml:lang="en">Liu B., Chen Y. X., Yin Q. et al. Diagnostic value and prognostic evaluation of Presepsin for sepsis in an emergency department. Crit Care 2013;17(5):R244.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Kojika M., Takahashi G., Matsumoto N. et al. Serum levels of soluble CD14 subtype reflect the APACHE II and SOFA scores. Med Postgrad 2010;48:46–50.</mixed-citation><mixed-citation xml:lang="en">Kojika M., Takahashi G., Matsumoto N. et al. Serum levels of soluble CD14 subtype reflect the APACHE II and SOFA scores. Med Postgrad 2010;48:46–50.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Spanuth E., Ebelt H., Ivandic B. et al. Diagnostic and prognostic value of presepsin (soluble CD14 subtype) in emergency patients with early sepsis using the new assay PATHFAST Presepsin. 21st International Congress of Clinical Chemistry and Laboratory Medicine, 2011. Poster 0333.</mixed-citation><mixed-citation xml:lang="en">Spanuth E., Ebelt H., Ivandic B. et al. Diagnostic and prognostic value of presepsin (soluble CD14 subtype) in emergency patients with early sepsis using the new assay PATHFAST Presepsin. 21st International Congress of Clinical Chemistry and Laboratory Medicine, 2011. Poster 0333.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Spanuth E., Wilhelm J., Loppnow H. et al. Utility of PATHFAST Presepsin in Septic Patients Admitted to the Emergency Room. 1st Central and Eastern European Sepsis Forum SepsEast. Budapest, September 19–23, 2012.</mixed-citation><mixed-citation xml:lang="en">Spanuth E., Wilhelm J., Loppnow H. et al. Utility of PATHFAST Presepsin in Septic Patients Admitted to the Emergency Room. 1st Central and Eastern European Sepsis Forum SepsEast. Budapest, September 19–23, 2012.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Ulla M., Pizzolato E., Lucchiari M. et al. Diagnostic and prognostic value of Presepsin in the management of sepsis in the emergency department: a multicentre prospective study. Crit Care 2013;17(4):R168.</mixed-citation><mixed-citation xml:lang="en">Ulla M., Pizzolato E., Lucchiari M. et al. Diagnostic and prognostic value of Presepsin in the management of sepsis in the emergency department: a multicentre prospective study. Crit Care 2013;17(4):R168.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Romualdo L. G., Torrella P. E., González M. V. Diagnostic accuracy</mixed-citation><mixed-citation xml:lang="en">Romualdo L. G., Torrella P. E., González M. V. Diagnostic accuracy</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">of presepsin (soluble CD14 subtype) for prediction of bacteremia in patients with systemic inflammatory response syndrome in the Emergency Department. Clin Biochem 2014;47(7–8):505–8.</mixed-citation><mixed-citation xml:lang="en">of presepsin (soluble CD14 subtype) for prediction of bacteremia in patients with systemic inflammatory response syndrome in the Emergency Department. Clin Biochem 2014;47(7–8):505–8.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Cebreiros-Lopez I., Noguera-Velasco J. A., Martinez-Ruiz A. et al. Correlation of Presepsin (SCD14-ST) with PCT in critically ill patients: Diagnostics usefulness in Sepsis. Euro Med Lab 2013. Poster M097.</mixed-citation><mixed-citation xml:lang="en">Cebreiros-Lopez I., Noguera-Velasco J. A., Martinez-Ruiz A. et al. Correlation of Presepsin (SCD14-ST) with PCT in critically ill patients: Diagnostics usefulness in Sepsis. Euro Med Lab 2013. Poster M097.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Chenevier-Gobeaux C., Trabattoni E., Roelens M. et al. Presepsin (sCD14-ST) in emergency department: the need for adapted threshold values? Clin Chim Acta 2014; 427:34–6.</mixed-citation><mixed-citation xml:lang="en">Chenevier-Gobeaux C., Trabattoni E., Roelens M. et al. Presepsin (sCD14-ST) in emergency department: the need for adapted threshold values? Clin Chim Acta 2014; 427:34–6.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Masson S., Caironi P., Spanuth E. et al. Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care 2014;18(1):R6.</mixed-citation><mixed-citation xml:lang="en">Masson S., Caironi P., Spanuth E. et al. Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care 2014;18(1):R6.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Shirakawa K. Diagnosis of respiratory tract infectious disease using urine specimens. European Patent Application EP 2 711 710 A1.</mixed-citation><mixed-citation xml:lang="en">Shirakawa K. Diagnosis of respiratory tract infectious disease using urine specimens. European Patent Application EP 2 711 710 A1.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Sargentini V., Ceccarelli G., D,Alessandro M. et al. Presepsin as a potential marker for bacterial infection relapse in critical care patients. A preliminary study. Clin Chem Lab Med 2015;53(4):567–73.</mixed-citation><mixed-citation xml:lang="en">Sargentini V., Ceccarelli G., D,Alessandro M. et al. Presepsin as a potential marker for bacterial infection relapse in critical care patients. A preliminary study. Clin Chem Lab Med 2015;53(4):567–73.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Spanuth E., Giannitsis E. Diagnosis of sespis and monitoring of weaning from mechanical ventilation in critical ill patients by PATHFAST Presepsin. 20th IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine. May 19–23, 2013. Milano, Italy. T022.</mixed-citation><mixed-citation xml:lang="en">Spanuth E., Giannitsis E. Diagnosis of sespis and monitoring of weaning from mechanical ventilation in critical ill patients by PATHFAST Presepsin. 20th IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine. May 19–23, 2013. Milano, Italy. T022.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Vodnik T., Kaljevic G., Tadicet T. еt al. Presepsin (sCD14-ST) in preoperative diagnosis of abdominal sepsis. Clin Chem Lab Med 2013;51(10):2053–62.</mixed-citation><mixed-citation xml:lang="en">Vodnik T., Kaljevic G., Tadicet T. еt al. Presepsin (sCD14-ST) in preoperative diagnosis of abdominal sepsis. Clin Chem Lab Med 2013;51(10):2053–62.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Novelli G., Morabito V., Ferretti G. et al. Pathfast presepsin assay for early diagnosis of bacterial infections in surgical patients: preliminary study. Transplant Proc 2013;45(7):2750–3.</mixed-citation><mixed-citation xml:lang="en">Novelli G., Morabito V., Ferretti G. et al. Pathfast presepsin assay for early diagnosis of bacterial infections in surgical patients: preliminary study. Transplant Proc 2013;45(7):2750–3.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Демидова В. С., Ушакова Т. А., Звягин А. А. и др. Пресепсин в диагностике гнойных осложнений у хирургических больных и пациентов с ожоговой травмой при критических состояниях. Материалы XV сессии МНОАР 28 марта 2014 г.</mixed-citation><mixed-citation xml:lang="en">Демидова В. С., Ушакова Т. А., Звягин А. А. и др. Пресепсин в диагностике гнойных осложнений у хирургических больных и пациентов с ожоговой травмой при критических состояниях. Материалы XV сессии МНОАР 28 марта 2014 г.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">С. 16–7. [Demidova V. S., Ushakova T. A., Zvyagin A. A. et al. Presepsin in diagnostics of purulent complications of surgical patients and patients with burn injuries in critical states. Materials of the XV Session of the Moscow Scientific Society of Anesthesiologists and Resuscitators, March 28, 2014. Pp. 16–7 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">С. 16–7. [Demidova V. S., Ushakova T. A., Zvyagin A. A. et al. Presepsin in diagnostics of purulent complications of surgical patients and patients with burn injuries in critical states. Materials of the XV Session of the Moscow Scientific Society of Anesthesiologists and Resuscitators, March 28, 2014. Pp. 16–7 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Попов Д. А., Плющ М. Г., Овсеенко С. Т. и др. Мониторинг уровня SCD14-ST (пресепсина) в предоперационном периоде</mixed-citation><mixed-citation xml:lang="en">Попов Д. А., Плющ М. Г., Овсеенко С. Т. и др. Мониторинг уровня SCD14-ST (пресепсина) в предоперационном периоде</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">у кардиохирургических больных. Анестезиология и реаниматология 2013;3:30–5. [Popov D. A., Plyushch M. G., Ovseyenko S. T. et al. Monitoring of the level of SCD14-ST (Presepsin) during the pre-surgery period of cardiac surgery patients. Ansteziologiya</mixed-citation><mixed-citation xml:lang="en">у кардиохирургических больных. Анестезиология и реаниматология 2013;3:30–5. [Popov D. A., Plyushch M. G., Ovseyenko S. T. et al. Monitoring of the level of SCD14-ST (Presepsin) during the pre-surgery period of cardiac surgery patients. Ansteziologiya</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">i reanimatologiya = Anesthesiology and Intensive Care 2013;3:30–5. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">i reanimatologiya = Anesthesiology and Intensive Care 2013;3:30–5. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Свирко Ю. С., Кулагина И. В., Подоксенов Ю.К. и др. Использование пресепсина в диагностике системного воспалительного ответа в послеоперационном периоде</mixed-citation><mixed-citation xml:lang="en">Свирко Ю. С., Кулагина И. В., Подоксенов Ю.К. и др. Использование пресепсина в диагностике системного воспалительного ответа в послеоперационном периоде</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">у кардиохирургических пациентов с ишемической болезнью сердца. Лаборатория 2014;2:56. [Svirko Yu. S., Kulagina I. V., Podoksenov Yu. K. et al. Application of presepsin in diagnostics of systemic inflammatory response during the inflammatory period of cardiac surgery patients with ischemic heart disease. Laboratoriya = Laboratory 2014;2:56. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">у кардиохирургических пациентов с ишемической болезнью сердца. Лаборатория 2014;2:56. [Svirko Yu. S., Kulagina I. V., Podoksenov Yu. K. et al. Application of presepsin in diagnostics of systemic inflammatory response during the inflammatory period of cardiac surgery patients with ischemic heart disease. Laboratoriya = Laboratory 2014;2:56. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Полякова И. Н., Андросова М. В., Мазанов М. Х., Годков М. А. Динамика уровня пресепсина в крови у больных с ишемической болезнью сердца, оперированных в условиях искусственного кровообращения. VII научно-практическая конференция «Современные технологии и методы диагностики различных групп заболеваний, лабораторный анализ». Тезисы. Москва, 14 мая 2014 г. [Polyakova I. N., Androsova M. V., Mazanov M.Kh., Godkov M. A. Dynamics of the presepsin level in blood of patients with ischemic heart disease after surgeries in conditions of artificial blood circulation. The VII Research and Practical Conference “State-of-Art Technologies and Methods of Diagnostics of Various Disease Groups, Laboratory Analysis”. Theses. Moscow, May 14, 2014. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Полякова И. Н., Андросова М. В., Мазанов М. Х., Годков М. А. Динамика уровня пресепсина в крови у больных с ишемической болезнью сердца, оперированных в условиях искусственного кровообращения. VII научно-практическая конференция «Современные технологии и методы диагностики различных групп заболеваний, лабораторный анализ». Тезисы. Москва, 14 мая 2014 г. [Polyakova I. N., Androsova M. V., Mazanov M.Kh., Godkov M. A. Dynamics of the presepsin level in blood of patients with ischemic heart disease after surgeries in conditions of artificial blood circulation. The VII Research and Practical Conference “State-of-Art Technologies and Methods of Diagnostics of Various Disease Groups, Laboratory Analysis”. Theses. Moscow, May 14, 2014. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Sponholz C., Sakr Y., Reinhart K., Brunkhorst F. Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature. Crit Care 2006;10(5):R145.</mixed-citation><mixed-citation xml:lang="en">Sponholz C., Sakr Y., Reinhart K., Brunkhorst F. Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature. Crit Care 2006;10(5):R145.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Aouifi A., Piriou V., Blanc P. et al. Effect of cardiopulmonary bypass on serum procalcitonin and C-reactive protein concentrations. Br J Anaesth 1999;83(4):602–7.</mixed-citation><mixed-citation xml:lang="en">Aouifi A., Piriou V., Blanc P. et al. Effect of cardiopulmonary bypass on serum procalcitonin and C-reactive protein concentrations. Br J Anaesth 1999;83(4):602–7.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Cakır Madenci O., Yakupoğlu S., Benzonana N. et al. Evaluation of soluble CD14 subtype (presepsin) in burn sepsis. Burns 2013;40(4):664–9.</mixed-citation><mixed-citation xml:lang="en">Cakır Madenci O., Yakupoğlu S., Benzonana N. et al. Evaluation of soluble CD14 subtype (presepsin) in burn sepsis. Burns 2013;40(4):664–9.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Beale R., Reinhart K., Brunkhorst F. M. et al. Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry. Infection 2009,37(3):222–32.</mixed-citation><mixed-citation xml:lang="en">Beale R., Reinhart K., Brunkhorst F. M. et al. Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry. Infection 2009,37(3):222–32.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Gando S., Iba T., Eguchi Y. et al. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med 2006;34(3):625–31.</mixed-citation><mixed-citation xml:lang="en">Gando S., Iba T., Eguchi Y. et al. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med 2006;34(3):625–31.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Ishikura H., Nishida T., Murai A. et al. New diagnostic strategy for sepsis-induced disseminated intravascular coagulation:</mixed-citation><mixed-citation xml:lang="en">Ishikura H., Nishida T., Murai A. et al. New diagnostic strategy for sepsis-induced disseminated intravascular coagulation:</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">a prospective single-center observational study. Crit Care 2014;18(1):R19.</mixed-citation><mixed-citation xml:lang="en">a prospective single-center observational study. Crit Care 2014;18(1):R19.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Urbonas V., Eidukaitė A., Tamulienė I. The predictive value of soluble biomarkers (CD14 subtype, interleukin-2 receptor, human leucocyte antigen-G) and procalcitonin in the detection of bacteremia and sepsis in pediatric oncology patients with chemotherapy-induced febrile neutropenia. Cytokine 2013;62(1):34–7.</mixed-citation><mixed-citation xml:lang="en">Urbonas V., Eidukaitė A., Tamulienė I. The predictive value of soluble biomarkers (CD14 subtype, interleukin-2 receptor, human leucocyte antigen-G) and procalcitonin in the detection of bacteremia and sepsis in pediatric oncology patients with chemotherapy-induced febrile neutropenia. Cytokine 2013;62(1):34–7.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Makarova P., Galstyan G., Krechetova A. et al. Usefulness of presepsin (PSP) for assessment of sepsis in leukopeniс patients (pts). Abstr. 27th Annual Congress, ESICM LIVES 2014, Barcelona, Spain, 27 September – 1 October 2014. Crit Care 2014.</mixed-citation><mixed-citation xml:lang="en">Makarova P., Galstyan G., Krechetova A. et al. Usefulness of presepsin (PSP) for assessment of sepsis in leukopeniс patients (pts). Abstr. 27th Annual Congress, ESICM LIVES 2014, Barcelona, Spain, 27 September – 1 October 2014. Crit Care 2014.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Chiesa C., Natale F., Pascone R. et al. C reactive protein and procalcitonin: Reference intervals for preterm and term newborns during the early neonatal period. Clin Chim Acta 2011;412(11–12):1053–9.</mixed-citation><mixed-citation xml:lang="en">Chiesa C., Natale F., Pascone R. et al. C reactive protein and procalcitonin: Reference intervals for preterm and term newborns during the early neonatal period. Clin Chim Acta 2011;412(11–12):1053–9.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Mussap M., Puxeddu E., Burrai P. et al. Soluble CD14 subtype (sCD14-ST) presepsin in critically ill preterm newborns: preliminary reference ranges. J Matern Fetal Neonatal Med 2012;25(Suppl 5):51–3.</mixed-citation><mixed-citation xml:lang="en">Mussap M., Puxeddu E., Burrai P. et al. Soluble CD14 subtype (sCD14-ST) presepsin in critically ill preterm newborns: preliminary reference ranges. J Matern Fetal Neonatal Med 2012;25(Suppl 5):51–3.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Casani A., Cocca F., Coletta C. et al. Presepsin values in health mature and near term neonates using new immunoassay:</mixed-citation><mixed-citation xml:lang="en">Casani A., Cocca F., Coletta C. et al. Presepsin values in health mature and near term neonates using new immunoassay:</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">a preliminary study. Abstract. J Pediatr Neonat Individualized Med 2012;1(1):56.</mixed-citation><mixed-citation xml:lang="en">a preliminary study. Abstract. J Pediatr Neonat Individualized Med 2012;1(1):56.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Kwiatkowska-Gruca M., Behrendt J., Sonsala A. et al. Presepsyna (rozpuszczalny podtyp CD14-ST) jako diagnostyczny biomarker posocznicy u noworodków. Pediatria Polska 2013;88(5):392–7.</mixed-citation><mixed-citation xml:lang="en">Kwiatkowska-Gruca M., Behrendt J., Sonsala A. et al. Presepsyna (rozpuszczalny podtyp CD14-ST) jako diagnostyczny biomarker posocznicy u noworodków. Pediatria Polska 2013;88(5):392–7.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Abd Elaziz H. Diagnosis of neonatal using different sepsis markers. Abstract. 4th International Conference on Biomarkers and Clinical Research. July 15–17, 2013.</mixed-citation><mixed-citation xml:lang="en">Abd Elaziz H. Diagnosis of neonatal using different sepsis markers. Abstract. 4th International Conference on Biomarkers and Clinical Research. July 15–17, 2013.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Puxeddu E., Noto A., Mussap M. et al. Is soluble CD14 subtype (sCD14-ST) presepsin and early biomarker of neonatal sepsis? Yes</mixed-citation><mixed-citation xml:lang="en">Puxeddu E., Noto A., Mussap M. et al. Is soluble CD14 subtype (sCD14-ST) presepsin and early biomarker of neonatal sepsis? Yes</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">it is. Neonat Individualized Med 2012;1(1):56.</mixed-citation><mixed-citation xml:lang="en">it is. Neonat Individualized Med 2012;1(1):56.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Козлова Е. М., Шунькина Г. Л., Чумак Н.М. и др. Уровень пресепсина крови у новорожденных детей. Лаборатория 2014;2:31. [Kozlova E. M., Shun,kina G. L., Chumak N. M. et al. The level of presepsin fluid of newborn babies. Laboratoriya = Laboratory 2014;2:31. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Козлова Е. М., Шунькина Г. Л., Чумак Н.М. и др. Уровень пресепсина крови у новорожденных детей. Лаборатория 2014;2:31. [Kozlova E. M., Shun,kina G. L., Chumak N. M. et al. The level of presepsin fluid of newborn babies. Laboratoriya = Laboratory 2014;2:31. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Плющ М. Г., Рогальская Е. А., Самсонова Н.Н. и др. Информативность уровней пресепсина для стратификации риска у пациентов после операций на сердце и сосудах. Лаборатория 2014;2:49. [Plyushch M. G., Rogalskaya E. A., Samsonova N. N. et al. Informative nature of presepsin levels for stratification</mixed-citation><mixed-citation xml:lang="en">Плющ М. Г., Рогальская Е. А., Самсонова Н.Н. и др. Информативность уровней пресепсина для стратификации риска у пациентов после операций на сердце и сосудах. Лаборатория 2014;2:49. [Plyushch M. G., Rogalskaya E. A., Samsonova N. N. et al. Informative nature of presepsin levels for stratification</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">of risks of patients after cardiovascular surgeries. Laboratoriya = Laboratory 2014;2:49. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">of risks of patients after cardiovascular surgeries. Laboratoriya = Laboratory 2014;2:49. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Malíčková K., Koucký M., Pařízek A. et al. Diagnostic and prognostic value of presepsin in preterm deliveries. J Matern Fetal Neonatal Med 2014:1–26.</mixed-citation><mixed-citation xml:lang="en">Malíčková K., Koucký M., Pařízek A. et al. Diagnostic and prognostic value of presepsin in preterm deliveries. J Matern Fetal Neonatal Med 2014:1–26.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Tsuji S., Ohshima S., Yura A. et al. Serum presepsin (soluble CD14-subtypr) as a novel useful biomarker for infection in patients with rheumatoid arthritis (RA). Ann Rheum Dis 2013;72(Suppl3):314.</mixed-citation><mixed-citation xml:lang="en">Tsuji S., Ohshima S., Yura A. et al. Serum presepsin (soluble CD14-subtypr) as a novel useful biomarker for infection in patients with rheumatoid arthritis (RA). Ann Rheum Dis 2013;72(Suppl3):314.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Novelli G., Morabito V., Ferretti G. et al. Diagnostic value of prespesin in сirthroic patients. J Hepatol 2013;58(Suppl 1):S95–6.</mixed-citation><mixed-citation xml:lang="en">Novelli G., Morabito V., Ferretti G. et al. Diagnostic value of prespesin in сirthroic patients. J Hepatol 2013;58(Suppl 1):S95–6.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Okasha H., Elgohary A., Abd El Moety A. et al. Diagnostic and prognostic value of serum presepsin in cirrhotic patients with spontaneous bacterial peritonitis. Abstracts of 24th ECCMID Congress. Barcelona, May 10–13, 2014.</mixed-citation><mixed-citation xml:lang="en">Okasha H., Elgohary A., Abd El Moety A. et al. Diagnostic and prognostic value of serum presepsin in cirrhotic patients with spontaneous bacterial peritonitis. Abstracts of 24th ECCMID Congress. Barcelona, May 10–13, 2014.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Смирнов Г. В., Красносельский М. Я., Фролков В. В. и др. Пресепсин – эффективный маркер гнойно-септических осложнений острого панкреатита. Эфферентная терапия 2014;20(1):30. [Smirnov G. V., Krasnoselskiy M. Ya., Frolkov V. V. et al. Presepsin as an efficient market of purulent and septic complications of acute pancreatitis. Efferentnaya terapiya = Efferent Therapy 2014;20(1):30. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Смирнов Г. В., Красносельский М. Я., Фролков В. В. и др. Пресепсин – эффективный маркер гнойно-септических осложнений острого панкреатита. Эфферентная терапия 2014;20(1):30. [Smirnov G. V., Krasnoselskiy M. Ya., Frolkov V. V. et al. Presepsin as an efficient market of purulent and septic complications of acute pancreatitis. Efferentnaya terapiya = Efferent Therapy 2014;20(1):30. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Bagshaw S. M., George C., Bellomo R. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 2008;12(2):R47.</mixed-citation><mixed-citation xml:lang="en">Bagshaw S. M., George C., Bellomo R. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 2008;12(2):R47.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Matejovic M., Chvojka J., Radej J. et al. Sepsis and acute kidney injury are bidirectional. Contrib Nephrol 2011;174:78–88.</mixed-citation><mixed-citation xml:lang="en">Matejovic M., Chvojka J., Radej J. et al. Sepsis and acute kidney injury are bidirectional. Contrib Nephrol 2011;174:78–88.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Mehta R. L., Bouchard J., Soroko S. B. et al. Sepsis as a cause and consequence of acute kidney injury: Program to Improve Care in Acute Renal Disease. Intensive Care Med 2011;37(2):241–8.</mixed-citation><mixed-citation xml:lang="en">Mehta R. L., Bouchard J., Soroko S. B. et al. Sepsis as a cause and consequence of acute kidney injury: Program to Improve Care in Acute Renal Disease. Intensive Care Med 2011;37(2):241–8.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Lai T. S., Wang C. Y., Pan S. C. et al. Risk of developing severe sepsis after acute kidney injury: a population-based cohort study. Crit Care 2013;17(5):R231.</mixed-citation><mixed-citation xml:lang="en">Lai T. S., Wang C. Y., Pan S. C. et al. Risk of developing severe sepsis after acute kidney injury: a population-based cohort study. Crit Care 2013;17(5):R231.</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Maravic-Stojkovic V., Lausevic-Vuk L., Jovic M. et al. Levels of рresepsin and midregion-proadrenomedullin in septic patients with end-stage renal disease after cardiovascular surgery: 1-year follow up study. J Clin Exp Cardiol 2014;5:5.</mixed-citation><mixed-citation xml:lang="en">Maravic-Stojkovic V., Lausevic-Vuk L., Jovic M. et al. Levels of рresepsin and midregion-proadrenomedullin in septic patients with end-stage renal disease after cardiovascular surgery: 1-year follow up study. J Clin Exp Cardiol 2014;5:5.</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Nakamura Y., Ishikura H., Nishida T. et al. Usefulness of presepsin in the diagnosis of sepsis in acute kidney injury patients. Crit Care 2013;17(Suppl 2):36.</mixed-citation><mixed-citation xml:lang="en">Nakamura Y., Ishikura H., Nishida T. et al. Usefulness of presepsin in the diagnosis of sepsis in acute kidney injury patients. Crit Care 2013;17(Suppl 2):36.</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Nakamura Y., Ishikura H., Ichiki R. et al. Usefulness of presepsin and procalcitonin levels in the diagnosis of sepsis in patients with acute kidney injury. Crit Care 2014;18(Suppl 1):213.</mixed-citation><mixed-citation xml:lang="en">Nakamura Y., Ishikura H., Ichiki R. et al. Usefulness of presepsin and procalcitonin levels in the diagnosis of sepsis in patients with acute kidney injury. Crit Care 2014;18(Suppl 1):213.</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">Lu X. L., Xiao Z. H., Yang M. Y. et al. Diagnostic value of serum procalcitonin in patients with chronic renal insufficiency:</mixed-citation><mixed-citation xml:lang="en">Lu X. L., Xiao Z. H., Yang M. Y. et al. Diagnostic value of serum procalcitonin in patients with chronic renal insufficiency:</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">a systematic review and meta-analysis. Nephrol Dial Transplant 2013;28(1):122–9.</mixed-citation><mixed-citation xml:lang="en">a systematic review and meta-analysis. Nephrol Dial Transplant 2013;28(1):122–9.</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">Amour J., Birenbaum A., Langeron O. et al. Influence of renal dysfunction on the accuracy of procalcitonin for the diagnosis</mixed-citation><mixed-citation xml:lang="en">Amour J., Birenbaum A., Langeron O. et al. Influence of renal dysfunction on the accuracy of procalcitonin for the diagnosis</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">of postoperative infection after vascular surgery. Crit Care Med 2008;36:1147–54.</mixed-citation><mixed-citation xml:lang="en">of postoperative infection after vascular surgery. Crit Care Med 2008;36:1147–54.</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">Hattori T., Nishiyama H., Kato H. et al. Clinical value of procalcitonin for patients with suspected bloodstream infection. Am J Clin Pathol 2014;141(1):43–51.</mixed-citation><mixed-citation xml:lang="en">Hattori T., Nishiyama H., Kato H. et al. Clinical value of procalcitonin for patients with suspected bloodstream infection. Am J Clin Pathol 2014;141(1):43–51.</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">Яковлев А. Ю., Абрамов А. В., Серопян М.Ю. и др. Динамика лабораторных маркеров сепсиса при проведении селективной ЛПС-сорбции. Лаборатория 2014;2:69. [Yakovlev A. Yu., Abramov A. V., Seropyan M. Yu. et al. Dynamics of laboratory sepsis markers in the course of performance of selective LPS sorption. Laboratoriya = Laboratory 2014;2:69. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Яковлев А. Ю., Абрамов А. В., Серопян М.Ю. и др. Динамика лабораторных маркеров сепсиса при проведении селективной ЛПС-сорбции. Лаборатория 2014;2:69. [Yakovlev A. Yu., Abramov A. V., Seropyan M. Yu. et al. Dynamics of laboratory sepsis markers in the course of performance of selective LPS sorption. Laboratoriya = Laboratory 2014;2:69. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">Яковлев А. Ю., Зайцев Р. М., Ниязматов А. А. и др. Динамика лабораторных маркеров сепсиса во время продленной вено-венозной гемофильтрации. Медицинский альманах 2013;3:148–9. [Yakovlev A. Yu., Zaitsev R. M., Niyazmatov A. A. et al. Dynamics of laboratory sepsis markers in the course of continuous venovenous hemofiltration. Meditsinskiy al,manah = Medical Almanac 2013;3:148–9. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Яковлев А. Ю., Зайцев Р. М., Ниязматов А. А. и др. Динамика лабораторных маркеров сепсиса во время продленной вено-венозной гемофильтрации. Медицинский альманах 2013;3:148–9. [Yakovlev A. Yu., Zaitsev R. M., Niyazmatov A. A. et al. Dynamics of laboratory sepsis markers in the course of continuous venovenous hemofiltration. Meditsinskiy al,manah = Medical Almanac 2013;3:148–9. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">Liu B., Yin Q., Chen Y. X. et al. Role of presepsin (sCD14-ST) and the CURB65 scoring system in predicting severity and outcome of community-acquired pneumonia in an emergency department. Respir Med 2014;108(8):1204–13.</mixed-citation><mixed-citation xml:lang="en">Liu B., Yin Q., Chen Y. X. et al. Role of presepsin (sCD14-ST) and the CURB65 scoring system in predicting severity and outcome of community-acquired pneumonia in an emergency department. Respir Med 2014;108(8):1204–13.</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">Еремина Н. А., Ткаля Н. Г., Воронина Н.А. и др. Динамика пресепсина при антибактериальной терапии муковисцидоза на стадии обострения обструктивного слизисто-гнойного бронхита. Клинический случай. Лаборатория 2014;2:25. [Eryomina N. A., Tkalya N. G., Voronina N. A. et al. Presepsin dynamics in the antibacterial therapy of cystic fibrosis at the acute stage of obstructive mucopurulent bronchitis. Clinical case. Laboratoriya = Laboratory 2014;2:25. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Еремина Н. А., Ткаля Н. Г., Воронина Н.А. и др. Динамика пресепсина при антибактериальной терапии муковисцидоза на стадии обострения обструктивного слизисто-гнойного бронхита. Клинический случай. Лаборатория 2014;2:25. [Eryomina N. A., Tkalya N. G., Voronina N. A. et al. Presepsin dynamics in the antibacterial therapy of cystic fibrosis at the acute stage of obstructive mucopurulent bronchitis. Clinical case. Laboratoriya = Laboratory 2014;2:25. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">Spanuth E., Hess G., Giannitsis E. et al. Comparison of sCD14-ST (рresepsin) with еight biomarkers for mortality prediction</mixed-citation><mixed-citation xml:lang="en">Spanuth E., Hess G., Giannitsis E. et al. Comparison of sCD14-ST (рresepsin) with еight biomarkers for mortality prediction</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">in patients admitted with acute heart failure. 2014 AACC Annual Meeting Abstracts. B-331.</mixed-citation><mixed-citation xml:lang="en">in patients admitted with acute heart failure. 2014 AACC Annual Meeting Abstracts. B-331.</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">Spanuth E., Thomae R., Giannitsis E. Presepsin (sCD14-ST) in acute coronary syndromes and heart failure. 2014 AACC Annual Meeting Abstracts. B-343.</mixed-citation><mixed-citation xml:lang="en">Spanuth E., Thomae R., Giannitsis E. Presepsin (sCD14-ST) in acute coronary syndromes and heart failure. 2014 AACC Annual Meeting Abstracts. B-343.</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">Sinning C. R., Sinning J. M., Schulz A. et al. Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease. Circ J 2011;75(5): 118–91.</mixed-citation><mixed-citation xml:lang="en">Sinning C. R., Sinning J. M., Schulz A. et al. Association of serum procalcitonin with cardiovascular prognosis in coronary artery disease. Circ J 2011;75(5): 118–91.</mixed-citation></citation-alternatives></ref><ref id="cit117"><label>117</label><citation-alternatives><mixed-citation xml:lang="ru">Kafkas N., Venetsanou K., Patsilinakos S. et al. Procalcitonin in acute myocardial infarction. Acute Card Care 2008; 10(1):30–6.</mixed-citation><mixed-citation xml:lang="en">Kafkas N., Venetsanou K., Patsilinakos S. et al. Procalcitonin in acute myocardial infarction. Acute Card Care 2008; 10(1):30–6.</mixed-citation></citation-alternatives></ref><ref id="cit118"><label>118</label><citation-alternatives><mixed-citation xml:lang="ru">Picariello C., Lazzeri C., Chiostri M. et al. Procalcitonin in patients with acute coronary syndromes and cardiogenic shock submitted to percutaneous coronary intervention. Intern Emerg Med 2009;4(5):403–8.</mixed-citation><mixed-citation xml:lang="en">Picariello C., Lazzeri C., Chiostri M. et al. Procalcitonin in patients with acute coronary syndromes and cardiogenic shock submitted to percutaneous coronary intervention. Intern Emerg Med 2009;4(5):403–8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
